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- B-cell activating factor - Wikipedia
As an immunostimulant, BAFF (BLyS, TALL-1) is necessary for maintaining normal immunity Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency
- The BAFF APRIL system: Emerging functions beyond B cell biology and . . .
In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials
- B cell activating factor (BAFF): Structure, functions . . . - PubMed
The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion BAFF expression is closely linked with autoimmunity and is enhanced by genetic alterations and viral infections
- Baltic-American Freedom Foundation
BAFF scholars represent leaders in their respective fields in the Baltic region and around the globe
- B cell activating factor (BAFF): Structure, functions, autoimmunity and . . .
Belimumab, an anti-BAFF antibody, is the only biologic agent so far approved for SLE therapy The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion
- BAFF signaling in health and disease - PubMed
BAFF is a critical cytokine supporting the survival of mature naïve B cells, acting through the BAFFR receptor Recent studies show that BAFF and BAFFR are also required for the survival of memory B cells, autoimmune B cells as well as malignant chronic lymphocytic leukaemia (CLL) cells
- BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases . . .
It binds to three receptors: BAFFR, TACI, and BCMA that are differentially expressed by B cell subsets BAFFR is early expressed in circulating B cells and provides key signals for further maturation Here, we report that highly regulated BAFFR processing events modulate BAFF responses
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