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- Pks-positive Escherichia coli in tumor tissue and surrounding normal . . .
It has been reported that Escherichia coli (E coli) containing polyketide synthetase (pks) island contribute to colorectal carcinogenesis by producing colibactin, a polyketide-peptide genotoxin
- pks+ E. coli adhesins—The fine line between good and evil
In a recent issue of Nature, Jans et al identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E coli on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage
- Genomic characterization of Escherichia coli with a polyketide synthase . . .
The E coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer
- Colibactin-driven colon cancer requires adhesin-mediated . . . - Nature
Here, using the microbiota-dependent ZEB2-transgenic mouse model of invasive CRC 7, we demonstrate that the oncogenic potential of pks+ E coli critically depends on bacterial adhesion to
- Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis
Therefore, colibactin-producing E coli could be a new biomarker that predicts the anti-PD-1 response in CRC, and it might be of interest to clear gut lumen from pks+ E coli prior to providing immunotherapy in CRC patients
- Short-term mucosal disruption enables colibactin-producing E. coli to . . .
Using a gnotobiotic mouse model, we show that under homeostatic conditions, pks+ E coli do not directly interact with the epithelium or affect colonic integrity
- Physiological drivers of pks+ E. coli in colorectal cancer
Among these is pks+ Escherichia coli, which produces colibactin, a genotoxic compound that induces DNA damage and leaves a distinct mutational signature in healthy individuals and CRC patients
- Prevalence and implications of pKs-positive Escherichia coli in . . .
Recent research has shed light on the potential role of pKs-positive Escherichia coli (pKs + E coli) and colibactin in the development and progression of CRC Therefore, this review aimed to provide an updated analysis of the prevalence and implications of pKs + E coli in colorectal cancer
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