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- The Mechanisms Behind Rapid Antidepressant Effects of . . .
We found accumulating evidence to support that ketamine induces an increase in molecules involved in modulating neuroplasticity, and that these changes are paired with rapid antidepressant effects Molecules or complexes of high interest include glutamate, AMPA receptors (AMPAR), mTOR, BDNF TrkB, VGF, eEF2K, p70S6K, GSK-3, IGF2, Erk, and microRNAs
- Neuropharmacology of Ketamine and Its Use in the Treatment of . . .
Furthermore, blocking these receptors blocked ketamine’s antidepressant effects, suggesting a potential role for dopamine in ketamine’s antidepressant action However, the effects on monoaminergic signaling alone cannot fully explain the mechanisms behind ketamine’s antidepressant effects, as SSRIs and TCAs also modulate monoaminergic
- Ketamine and rapid antidepressant action: new treatments and . . .
Ketamine is an open channel blocker of ionotropic glutamatergic N -Methyl- D -Aspartate (NMDA) receptors The discovery of its rapid antidepressant effects in patients with depression and
- The Mechanisms Behind Rapid Antidepressant Effects of . . .
We found accumulating evidence to support that ketamine induces an increase in molecules involved in modulating neuroplasticity, and that these changes are paired with rapid antidepressant effects Molecules or complexes of high interest include glutamate, AMPA receptors (AMPAR), mTOR, BDNF TrkB, VGF, eEF2K, p70S6K, GSK-3, IGF2, Erk, and microRNAs
- Ketamine’s rapid and sustained antidepressant effects are . . .
In the present study, we show that the sustained behavioral effects of ketamine are mediated by a decrease in BMP signaling and an increase in AHN, without selectively altering the activity of immature neurons
- Bridging rapid and sustained antidepressant effects of ketamine
Here we review how ketamine triggers this intracellular signaling pathway to mediate synaptic plasticity which underlies the rapid antidepressant effects and links it to downstream signaling and the sustained antidepressant effects
- Ketamine for unipolar depression: A systematic review of . . .
Ketamine, originally an anaesthetic, has emerged as a rapid-acting antidepressant This systematic review evaluates ketamine’s efficacy and safety in unipolar depression
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