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- Human metapneumovirus: pathogenesis, epidemiology, diagnostic . . .
In this review, we summarize the structure of HMPV and its pathogenic mechanisms; discuss the molecular epidemiology and diagnostic techniques related to HMPV; and summarize the latest advances in the prevention and treatment of HMPV infections, particularly the development of neutralizing antibodies, vaccines, and antiviral drugs
- Human metapneumovirus and HMPV Infection Explained
The structure of HMPV includes an outer envelope (lipid bilayer) with three membrane surface glycoproteins: fusion protein (F), glycoprotein (G), and small hydrophobic protein (SH) They are in the form of spikes of approximately 13-17 nm
- Human metapneumovirus: understanding the molecular mechanisms and . . .
HMPV is a non-segmented negative-sense RNA virus in the Pneumoviridae family containing eight genes, totaling ~13 3 kb, that code for nine proteins The produced proteins can be divided into four groups: glycoproteins, polymerase complex, structural, and M2 proteins
- Human metapneumovirus - Wikipedia
HMPV is genetically similar to the avian metapneumoviruses A, B and in particular type C Phylogenetic analysis of HMPV has demonstrated the existence of two main genetic lineages termed subtype A and B containing within them the subgroups A1 A2 and B1 B2 respectively
- Frontiers | Human Metapneumovirus: Mechanisms and Molecular Targets . . .
It has a negative-sense, single-stranded RNA genome of about 13 Kb of length, encoding 9 structural proteins that go as follows: 3′-N-P-M-F-M2-SH-G-L-5′ (Figure 1) (16) The different effects of these proteins on the immune system of the host are not fully characterized
- About Human Metapneumovirus | Human Metapneumovirus | CDC
Discovered in 2001, HMPV is in the Pneumoviridae family along with respiratory syncytial virus (RSV) Broader use of molecular diagnostic testing has increased identification and awareness of HMPV as an important cause of upper and lower respiratory infection
- RCSB PDB - 6U5O: Structure of the Human Metapneumovirus Polymerase . . .
Here we report a cryo-electron microscopy reconstruction that shows the ring-shaped structure of the polymerase and capping domains of HMPV-L bound to a tetramer of P The connector and methyltransferase domains of L are mobile with respect to the core
- Human metapneumovirus (hMPV) infection
Human metapneumovirus (hMPV) is one of the viruses that causes the common cold (upper respiratory infection) It usually makes people only mildly sick, but it can make some people very sick
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