Can You Take A H2 Blocker With A PPI (Proton Pump Inhibitor)? Jwork asked Can you take H2 blockers with PPIs (proton pump inhibitors? I just started taking Protonix (pantoprazole) today 40 mg twice a day I am starting get indigestion Can I take Pepcid AC (famotidine) with it? Answer There a minor drug interaction between H2 blockers and PPIs (proton pump inhibitors), but only in terms of their conflicting mechanisms of action Due to how these