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- Targeted mRNA delivery with bispecific antibodies that tether . . .
Here, we present a generalizable method for targeted mRNA-LNP delivery that uses bispecific antibodies (BsAbs) to form a bridge between LNPs and cell surface markers BsAbs can be combined with LNPs or administered first, binding to surface proteins on target cells and later retaining unmodified LNPs in affected tissues
- Targeted mRNA delivery with bispecific antibodies that tether . . .
Here we present a generalisable method for targeted mRNA-LNP delivery that uses bispecific antibodies (BsAbs) to form a bridge between LNPs and cell-surface markers
- Studying how administration route and dose regulates antibody . . .
Here, we directly compared antibody generation against PEGylated mRNA-carrying LNPs administered by the intravenous, intramuscular, or subcutaneous route, using a novel sophisticated assay capable of measuring antibody binding to authentic LNP surfaces with single-particle resolution
- Straight to the point: targeted mRNA-delivery to immune cells . . .
To overcome these issues, mRNA targeted delivery comes up as a promising improvement Briefly, the purpose of an mRNA vaccine is to make cells process delivered mRNA and release the translated antigen or present the epitopes on the surface of the cells (Figure 1)
- mRNA nanodelivery systems: targeting strategies and . . .
Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized
- Targeted mRNA delivery with bispecific antibodies that tether . . .
Most tissues are inaccessible for systemic administration of lipid nanoparticle-formulated mRNA therapeutics Customizable bispecific antibodies bind to lipid nanoparticles and proteins on target cells, enabling cell-specific mRNA delivery and broadening the scope of mRNA applications
- A lung-selective delivery of mRNA encoding broadly . . .
In this study, we developed lung-selective LNPs that delivered mRNAs encoding a broadly neutralizing antibody, to the mouse lungs in a highly efficient manner; as a results, a remarkable therapeutic effect was achieved in the prevention and treatment of infection by SARS-CoV-2 variants
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