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- Dicer - Wikipedia
Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively These fragments are approximately 20–25 base pairs long with a two-base overhang on the 3′-end
- DICER: structure, function, and regulation - PMC
DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes DICER is encoded by a single gene in vertebrates and C elegans, although it can be present in more paralogs in other species
- DICER cleavage fidelity is governed by 5′-end binding pockets
DICER is an evolutionarily conserved RNase III enzyme that has a central role in RNA silencing, a crucial gene regulatory mechanism that influences diverse biological processes
- DICER: structure, function, and regulation - Springer
DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes DICER is encoded by a single gene in vertebrates and C elegans, although it can be present in more paralogs in other species
- Molecular mechanisms of Dicer: endonuclease and enzymatic activity
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional
- Structure of the human DICER–pre-miRNA complex in a dicing state
Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity towards long dsRNAs—unlike
- Dicer structure and function: conserved and evolving features
Dicer is a general name for RNase III endoribonucleases producing small RNAs for RNA silencing pathways There is a common order of specific modules present in Dicer across eukaryotic kingdoms, which reflects the common order of protein domains in the primary protein sequence
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