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- Gene Therapies in Atrial Fibrillation - Journal of Cardiovascular . . .
Gene therapy offers a promising way to modulate AF’s molecular drivers This review summarizes recent preclinical studies using viral and non-viral vectors, atrial-specific delivery strategies, and key targets such as ion channels, fibrosis, and oxidative stress
- The Genetic Mechanisms and Pathology of Atrial Fibrillation: A . . . - MDPI
Studies have identified both monogenic and polygenic contributors to AF risk Monogenic mutations, inherited in Mendelian patterns, often affect ion channels and regulatory proteins, while polygenic variants modulate susceptibility and interact with environmental factors
- Studies reveal new genetic roots of atrial fibrillation
Researchers double the number of genetic factors associated with this common arrhythmia, highlighting biological pathways that could be targeted by new medicines Atrial fibrillation is a common arrhythmia that can lead to heart disease and stroke
- The transcriptional landscape of atrial fibrillation: A systematic . . .
To understand the genome-wide transcriptomic landscape, we performed a meta-analysis from studies reporting gene expression patterns in atrial heart tissue from patients with AF and controls in sinus rhythm (SR)
- A gene regulatory network connects heart failure and atrial fibrillation
In summary, these results suggest that the gene-regulatory network guided by FOG2, TBX5 and GATA4 is important for the devel-opment of atrial fibrillation independently of structural tissue
- Genetics of Atrial Fibrillation by Jitae A Kim, Mihail G Chelu et al.
In addition to traditional risk factors, it is increasingly recognized that a genetic component underlies atrial fibrillation development This review aims to provide an overview of the genetic cause of atrial fibrillation and clinical applications, with a focus on recent developments
- Genetic testing in early-onset atrial fibrillation
Rare variant determinants of early-onset atrial fibrillation Consistent with the strong link between AF and cardiomyopathy, recent rare variant analyses have implicated myocardial structural genes in AF The gene TTN, which encodes the sarcomere protein titin, has been robustly associated with AF across studies and datasets
- Genomic data-driven framework for drug target discovery in atrial . . .
Atrial fibrillation (AF) is the most common type of arrhythmia and is linked to an increased risk of death, stroke, and other complications Although studies have explored the pathophysiology of AF, its genetic mechanisms remain poorly understood, limiting the development of effective treatments
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