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- Advances in biotechnological production of santalenes and santalols
In this review, we summarize biosynthetic enzymes of santalenes and santalols, including various santalene synthases (STSs) and cytochrome P450 monooxygenases (CYPs), and then highlight the advances of biotechnological production of santalenes and santalols in heterologous hosts, especially metabolic engineering strategies for constructing santa
- Optimized biosynthesis of santalenes and santalols in
In this paper, the “push-pull-inhibition” strategy was adopted to construct the biosynthetic pathway of santalenes by overexpression of mva (3-hydroxy-3-methylglutaryl coenzyme A reductase from Staphylococcus aureus, Accession No:CP009361), SaSS and ERG20 (farnesyl diphosphate synthase from S cerevisiae, Accession No:NM_001181600) in the strain
- Reconstruction of the Biosynthetic Pathway of Santalols under Control . . .
To alter flux from predominant triterpenoid steroid biosynthesis to sesquiterpenoid production, expression of ERG9 (encoding yeast squalene synthase) was depressed by replacing its innate promotor with P HXT1 and fermenting the resulting strains in galactose-rich media
- Optimized biosynthesis of santalenes and santalols in . . . - PubMed
Meanwhile, the optimized chimeric CYP736A167 opt -46tATR1 opt exhibits higher activity to oxidize santalenes into santalols It would provide a feasible solution for the optimal biosynthesis of santalols KEY POINTS: • First-time de novo synthesis of santalols by P450-CPR chimera in S cerevisiae
- Rationally engineering santalene synthase to readjust the component . . .
In this study, we sought to elevate the ratios of Z - α -santalol and Z - β -santalol through engineering santalene synthase to attenuate the production of exo - α -bergamotene and Z - exo - α
- Advances in biotechnological production of santalenes and santalols
Recently, the biosynthetic pathway of the santalenes (referring to α-santalene, β-santalene, epi-β-santalene and exo-α-bergamotene herein) and santalols (referring to α-santalol, β-santalol, epi-β-santalol, exo-α-bergamotol herein) has been revealed (Fig 1)
- Biosynthesis of Sandalwood Oil: Santalum album CYP76F Cytochromes P450 . . .
Four sesquiterpenols, α-, β-, and epi-β-santalol and α-exo-bergamotol, make up approximately 90% of the oil of Santalum album These compounds are the hydroxylated analogues of α-, β-, and epi -β-santalene and α- exo -bergamotene
- [Progress in biosynthesis of santalene and santalol] - PubMed
In this paper, the biosynthesis progress of santalene and santalol synthase, as well as the optimization of mevalonate metabolic pathways in the hosts are summarized
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