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- ERK_百度百科
ERK是extracellular regulated protein kinases的英文缩写，指细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从表面受体传导至细胞核的关键。 许多其他信号通路明显活化时，可活化蛋白激酶ERK信号通路，ERK明显活化时，也可活化其他信号通路。
- MAPK ERK pathway - Wikipedia
The ERK pathway plays an important role of integrating external signals from the presence of mitogens such as epidermal growth factor (EGF) into signaling events promoting cell growth and proliferation in many mammalian cell types
- ERK MAPK signalling pathway and tumorigenesis - PMC
ERK is a member of the MAPK family, and the ERK MAPK signalling pathway is the core of the signalling network involved in regulating cell growth, development and division
- ERK signalling: a master regulator of cell behaviour, life and fate
By phosphorylating widely diverse substrates, ERK proteins govern a variety of evolutionarily conserved cellular processes in metazoans, the dysregulation of which contributes to the cause of
- Extracellular Signal-Regulated Kinases - ScienceDirect
ERK has a unique position in the MAPK ERK pathway since its upstream RAF molecule has very limited effectors beside MEK, ERK as the only substrate Moreover, ERK is the sole activator capable of stimulating a wide range of downstream substrates regulating disease pathophysiology
- MAPK Erk in Growth and Differentiation - Cell Signaling Technology
Explore the ERK pathway and its role in cell proliferation and survival Click here to read more about this critical signaling pathway
- ERK Signal Transduction Pathway | R D Systems
Read our article on The ERK Signal Transduction Pathway and its role in growth factor signaling and cancer
- Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates - MDPI
Generally, ERK activation aligns with the Goldilocks principle in cell fate determination Inadequate or excessive ERK activity hinders cell proliferation, while balanced activation promotes both cell proliferation and survival
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