Action Sites and Clinical Application of HIF-1α Inhibitors Cells adapt to hypoxia by specifically regulating the expressions of certain genes or proteins through oxygen sensors and signaling transduction pathways, in which hypoxia inducible factor-1 (HIF-1) plays an important role
Epitranscriptomic regulation of HIF-1: bidirectional regulatory . . . Hypoxia-inducible factor-1 (HIF-1), a master regulator of the cellular response to low oxygen, plays a critical role in adaptive and pathological processes, including cancer, ischemic heart disease, and metabolic disorders