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- The Effects of Statin Therapy on Circulating Levels of . . . - PubMed
Results: Random-effects meta-analysis of 3 studies including 244 patients demonstrated a significant decrease in plasma TMAO levels after statin treatment (WMD: -1 839, 95% CI: -2 391, -1 287, p<0 001; I2 :0) The reduction in TMAO was robust in the leaveone-out sensitivity analysis
- Trimethylamine N-oxide in cardiovascular disease: Pathophysiology and . . .
Elevated TMAO levels are associated with atherosclerosis, heart failure, arrhythmia, and atrial fibrillation TMAO accelerates atherosclerosis by promoting vascular inflammation and reducing reverse cholesterol transport, which leads to lipid accumulation and vessel narrowing
- Atherosclerotic patients with diabetes mellitus may break through the . . .
Diabetics have abnormally high plasma TMAO levels even under continuous statins treatment, which may contribute to the development and progression of atherosclerosis Therefore, it is necessary to focus on monitoring TMAO levels in diabetic patients to reduce adverse cardiovascular events in diabetic patients
- Pathogenic Mechanisms of Trimethylamine N-Oxide-induced . . . - PubMed
An increasing number of clinical studies have demonstrated a strong relationship between elevated plasma TMAO levels and adverse cardiovascular events It is commonly agreed that TMAO acts as an independent risk factor and a prognostic index for patients with cardiovascular disease
- Atherosclerotic patients with diabetes mellitus may break through the . . .
Diabetics have abnormally high plasma TMAO levels even under continuous statins treatment, which may contribute to the development and progression of atherosclerosis Therefore, it is necessary to focus on monitoring TMAO levels in diabetic patients to reduce adverse cardiovascular events in diabetic patients 1 Introduction
- Trimethylamine N-oxide in cardiovascular disease: Pathophysiology and . . .
Elevated TMAO levels are associated with atherosclerosis, heart failure, arrhythmia, and atrial fibrillation TMAO accelerates atherosclerosis by promoting vascular inflammation and reducing reverse cholesterol transport, which leads to lipid accumulation and vessel narrowing
- The Accumulation and Molecular Effects of Trimethylamine N-Oxide on . . .
Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases has grown exponentially
- The associations between TMAO-related metabolites and blood lipids and . . .
Statistical methods were used to detect the associations between TMAO-related metabolites and blood lipids and determine how rosuvastatin therapy alters the levels of these metabolites A significant positive correlation was found between TMAO and triglycerides (TG) (r = 0 303, P < 0 05)
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