安裝中文字典英文字典辭典工具!
安裝中文字典英文字典辭典工具!
|
- Iron Homeostasis and the Inflammatory Response - PMC
In turn, the HIFs are major regulators of a number of genes involved in iron homeostasis and inflammation, including TfR1, heme oxygenase-1, Nramp1, DMT1, erythropoietin, Dcytb, and ferroportin Many of these factors directly contribute to mechanisms mediating the iron withdrawal response to inflammation as discussed later in this chapter
- The role of iron in chronic inflammatory diseases: from mechanisms to . . .
Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or cancer, that negatively affect disease outcome and quality of life The pathophysiology of AI is multifactorial, with inflammatory hypoferremia and iron-restricted erythropoiesis playing a major role in the context
- Iron homeostasis and ferroptosis in human diseases: mechanisms and . . .
Therefore, in-depth analysis of ferroptosis and its potential molecular mechanisms in human diseases may offer additional strategies for clinical prevention and treatment
- The role of iron homeostasis in remodeling immune function and . . .
Here, we review the timing and mechanisms by which systemic and cellular iron metabolism are regulated during the inflammatory response and during infectious disease, processes in which both the host and the pathogen compete for iron
- Iron metabolism and ferroptosis in human health and disease
In this review, we first describe the molecular mechanisms governing iron homeostasis at the levels of systemic and cellular metabolism We then review recent advancements in understanding the mechanisms underlying ferroptosis and imbalances in iron homeostasis in human diseases
- Chronic Inflammation and Iron Metabolism - PMC
Bacteria have evolved mechanisms to acquire iron in low iron environments that include the secretion and reuptake of iron-binding organic molecules termed siderophores Pathogens have developed the ability to acquire iron from host iron-binding proteins like hemoglobin, lactoferrin, and transferrin 4
- The Role of Iron Regulation in Immunometabolism and Immune . . . - Frontiers
In this review, we will however, highlight the specific role of iron metabolism at the cellular and organismal level, as well as how the bioavailability of this metal orchestrates complex metabolic programs in immune cell homeostasis and inflammation
- An overview of molecular basis of iron metabolism regulation and the . . .
Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, such as the alternative splicing, microRNAs, the IRP IRE system and the proteolytic cleavage
|
|
|