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- Excitotoxicity - Wikipedia
In 1969, John Olney discovered that the phenomenon was not restricted to the retina, but occurred throughout the brain, and coined the term excitotoxicity
- Molecular mechanisms of excitotoxicity and their relevance to the . . .
Building on that foundation, this update summarizes the latest research on the role of excitotoxicity in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington
- Excitotoxicity - an overview | ScienceDirect Topics
Excitotoxicity is a hyperacute secondary injury mechanism that initiates shortly after a brain insult It is characterized by pathologically high levels of excitatory neurotransmitters such as glutamate that allows excessive influx of calcium and sodium ions into the cell
- What Are Excitotoxins and How Do They Damage the Brain?
Excitotoxicity is a major mechanism of neuronal death across a spectrum of neurological conditions, from acute injury to chronic neurodegenerative diseases In acute events, such as ischemic stroke or traumatic brain injury, a sudden and massive release of glutamate occurs
- Excitotoxicity: Still Hammering the Ischemic Brain in 2020
Although excitotoxicity was originally described as specific to neurons, oligodendrocytes express a full array of glutamate receptors (Káradóttir and Attwell, 2007) and are highly vulnerable to excitotoxic injury and death
- Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Excitotoxicity describes the phenomenon whereby neurons are killed or injured following overactivation of excitatory receptors leading to calcium overload
- Excitotoxicity and cell damage - ScienceDaily
Excitotoxicity is the pathological process by which neurons are damaged and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and
- Various facets of excitotoxicity
Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common excitotoxicity trigger
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