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- Cocaine - StatPearls - NCBI Bookshelf - National Center for . . .
This activity reviews the mechanism of action, adverse event profile, toxicity, dosing, pharmacodynamics, and monitoring of cocaine pertinent for interprofessional team members when used as indicated in the clinical setting
- Cocaine: An Updated Overview on Chemistry, Detection, Biokinetics, and . . .
Cocaine can exert local anaesthetic action by inhibiting voltage-gated sodium channels, thus halting electrical impulse propagation; cocaine also impacts neurotransmission by hindering monoamine reuptake, particularly dopamine, from the synaptic cleft
- Cocaine: Uses, Interactions, Mechanism of Action - DrugBank Online
Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities Mechanism of action Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves
- Cocaine: Mechanism and Effects in the Human Brain
As with other drugs of abuse, cocaine changes the signaling of the endogenous neurotransmitters in the brain Its effects on the dopamine system have been shown to be most directly correlated with addiction and closely associated with alteration of motivated, reward-driven behavior
- cocaine [TUSOM | Pharmwiki] - Tulane University
Mechanism of Action: low concentrations block monoamine reuptake transport into nerve terminals (All three types: NET, DAT SERT) (Kd ≈ 0 3 uM for NET) NOTE: Cocaine non-selectively blocks the membrane transporters for norepinephrine, dopamine and serotonin (which are different gene products)
- Cocaine - National Institute on Drug Abuse (NIDA)
How does cocaine work in the brain? What are the short-term effects of cocaine use? What are the long-term effects of cocaine use? How does cocaine use affect pregnancy? How is cocaine use disorder treated? Addiction often goes hand-in-hand with other mental illnesses Both must be addressed
- The Neurobiology of Cocaine Addiction - PMC - PubMed Central (PMC)
Snorted, smoked, or injected, cocaine rapidly enters the bloodstream and penetrates the brain The drug achieves its main immediate psychological effect—the high—by causing a buildup of the neurochemical dopamine Dopamine acts as a pacesetter for many nerve cells throughout the brain
- Chapter 154 – Cocaine and Other Sympathomimetics - CanadiEM
Mechanism of Action: cocaine causes release of dopamine, epinephrine, norepinephrine, and serotonin This, in turn, causes the following: Please refer to Box 149 1 in Rosen’s 9th Edition for a comprehensive table of the clinical manifestations of cocaine toxicity
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