Insulin signaling disruption exacerbates memory impairment . . . In conclusion, a low-dose icv-STZ injection exacerbates memory deficits and seizure susceptibility in the WAR strain by disturbing downstream proteins involved in insulin signaling This highlights the implications of brain insulin resistance in both AD and epilepsy
Insulin Resistance in the Brain may Link Alzheimer’s and Epilepsy New research has shown that the process of insulin resistance in the brain affects both Alzheimer’s disease and epilepsy and may be a linking factor between the two diseases The findings confirm clinical evidence that people with epilepsy are at greater risk of developing Alzheimer’s disease as they age
Brain insulin resistance in Alzheimers disease and related . . . Insulin affects Alzheimer's disease pathology directly via its interactions with the Aβ peptide 12 Insulin protects against Aβ synaptotoxicity and modulates clearance through its effects on lipid metabolism and proteases, such as the insulin degrading enzyme 12 A study showed that insulin resistance in the periphery in patients with