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- Galectin Therapeutics
Galectin Therapeutics develops novel therapies to improve the lives of patients with chronic liver disease and cancer Galectin’s lead drug, belapectin (GR‑MD‑02), is a carbohydrate-based drug that inhibits the galectin‑3 protein, involved in many inflammatory, fibrotic, and malignant diseases
- The role of galectins in immunity and infection - Nature
Galectins can be located in the nucleus or the cytoplasm, or can be secreted into the extracellular space They can modulate innate and adaptive immune cells by binding to glycans on the surface
- Galectin-3 as a novel biomarker for disease diagnosis and a target for . . .
Galectin-3 is a member of the galectin family, which are β-galactoside-binding lectins with ≥1 evolutionary conserved carbohydrate-recognition domain It binds proteins in a carbohydrate-dependent and -independent manner
- Galectins - Essentials of Glycobiology - NCBI Bookshelf
Galectins are among the most widely expressed class of lectins in all organisms They typically bind β-galactose-containing glycoconjugates and share primary structural homology in their carbohydrate-recognition domains (CRDs)
- Galectins: Current Biology - Cell Press
Galectins are β-galactoside-binding animal lectins that contain one or two conserved carbohydrate recognition domains (CRDs) consisting of approximately 130 amino acids
- The universe of galectin-binding partners and their functions in health . . .
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in diverse biological processes including tissue repair, adipogenesis, immune cell homeostasis, angiogenesis, and pathogen recognition
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