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- One shot to stop HIV: MITs bold vaccine breakthrough
One shot to stop HIV: MIT's bold vaccine breakthrough By delivering an HIV vaccine candidate along with two adjuvants, researchers showed they could generate many more HIV-targeting B cells in mice
- Supercharged vaccine could offer strong protection with just . . .
Researchers generated a strong immune response to HIV with just one vaccine dose, by adding two powerful adjuvants to the vaccine This strategy could lead to vaccines that only need to be given once, for infectious diseases including HIV or SARS-CoV-2
- Step by Step Scientists Move Closer to an HIV Vaccine . . .
The key stumbling block? Training the immune system to produce broadly neutralizing antibodies (bnAbs), rare molecules that can strike at the conserved core of HIV across its many variants Generating these bnAbs is like asking a novice painter to recreate a masterpiece after just one lesson
- One Shot To Stop HIV: MITs Bold Vaccine Breakthrough
ScienceDaily reports: Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies
- Groundbreaking single-dose vaccine found effective in . . .
Scientists have developed a vaccine which provides a strong immune response against HIV in mice, an advance that could lead to potent single-dose vaccines for a range of infectious diseases The
- Single-Dose HIV Vaccine Shows Promise With Dual Adjuvants . . .
“This approach is compatible with many protein-based vaccines, so it offers the opportunity to engineer new formulations for these types of vaccines across a wide range of different diseases, such as influenza, SARS-CoV-2, or other pandemic outbreaks,” says J Christopher Love, the Raymond A and Helen E St Laurent Professor of Chemical Engineering at MIT, and a member of the Koch
- Always ‘one atom away’: The long, rocky journey to an HIV . . .
But antiretrovirals must be used in combination to prevent the emergence of resistant viruses, and lenacapavir had no obvious partners because no other HIV drug works for 6 months with one dose So Gilead focused on the niche market of using lenacapavir injections as a “salvage treatment” for people who were failing on other anti-HIV drugs
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