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- Behavioral phenotyping for autism spectrum disorders in mice
Change testing room lighting to 100 lux Habituate singly-housed test mice and novel mice in the testing room for at least an hour before testing 2 Fifteen minutes before testing, apply a non- toxic marker on the back fur of the test and the novel mice The procedure may be repeated just before testing
- Behavioral Tests for Mouse Models of Autism: An Argument for . . .
However, there are many differences between mice and humans, which makes interpreting behaviors challenging Here, we discuss a battery of behavioral tests for specific mouse behaviors to explore whether each test does indeed evaluate the intended measure, and whether these tests are useful in learning about ASD
- Mouse Behavioral Assays Relevant to the Symptoms of Autism
We are engaged in a growing initiative to develop behavioral tests for mice that approximate the core symptoms of autism spectrum disorders in humans Autism is a neurodevelopmental disorder with a strong genetic basis 3, 38, 64, 97, 98, 137, 155, 169, 186, 201, 203
- Advances in behavioral genetics: mouse models of autism
Our research group has proposed a set of behavioral tests that can be used to assess social deficits and repetitive behavior in mice 17, 18, 19 The testing screen includes assays for social
- Autism in Mice: Developing Behavioral Standards - Maze Engineers
With a rich set of classical and ASD-specific behavioral assays, researchers have the means to validate mouse models and study ASD in a comprehensive way Behavioral phenotyping in animal models uses the three main criteria for diagnosing ASD: social interaction, communication, and repetitive behaviors
- Behavioral Tests for Mouse Models of Autism: An Argument for . . .
The Eyeblink Conditioning Test is of Great Value in ASD Research Three gradient bars compare ASD symptoms and murine behavioral tests from least weakest to most strongest The blue bar addresses whether the behavior each murine test purports to examine has been seen as a parallel human behavior in individuals with ASD
- Behavioural phenotyping assays for mouse models of autism
Although there is not a consistent vocalization endophenotype for autism during the first 2 years of life in humans (which would correspond to the pup stage in mice), ongoing studies are evaluating the relevance of juvenile and adult vocalizations in mouse models to the specific types of communication abnormalities in autism 29,84,89,135
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