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- Pathology Outlines - Hobnail
FNAC can suspect hobnail variant and influence surgical tactics PTC hobnail variant requires at least 30% of tumor having hobnail-micropapillary pattern Minor hobnail micropapillary features (5 - 30%) should also be correctly identified and stated in pathology report due to potential aggressive behavior (Hum Pathol 2012;43:1596)
- Pathology Outlines - Hemangioma variants
Hobnail hemangioma: hobnail nuclei protruding into vascular lumina; circumscribed Infantile hemangioma: Proliferation of capillary lobules; has a distinct natural history involving three stages (i e , proliferation, partial regression and complete regression):
- Pathology Outlines - Clear cell carcinoma
Low cuboidal, polyhedral, hobnail or flattened cells with uniform nuclear atypia, prominent nucleoli and variable mitotic activity (usually low at < 6 per 10 high power fields) Hobnail cells have hyperchromatic nuclei protruding into lumina of tubulocystic structures or lining papillae Focal nuclear pleomorphism may be present in 40%
- Pathology Outlines - Retiform hemangioendothelioma
Shows mixture of more than hemangioendothelioma types, including Dabska tumor, retiform hemangioendothelioma and hobnail hemangioendothelioma, etc in various combinations Whenever possible, thorough sampling should be done to exclude a possibility of composite hemangioendothelioma when any hemangioendothelioma pattern is encountered
- Pathology Outlines - Clear cell carcinoma
Hobnail cells and flat cells Occasional enlarged irregular nucleoli Variable cytological atypia Relatively low mitotic index High mitotic index or pleomorphic nuclei does not rule out clear cell carcinoma in an otherwise typical tumor Occasionally targetoid bodies, eosinophilic globules or psammoma bodies
- Pathology Outlines - Glandular odontogenic cyst
Apocrine snouting of hobnail cells: Hobnail cells may demonstrate "pinching off" of surface similar to decapitation secretion seen in cells that line apocrine gland ducts Mucous goblet cells: Present individually or in small clusters on cyst lumen surface or within cyst lining May also line microcysts Not specific for GOC diagnosis Ciliated
- Pathology Outlines - Hemangioma
Scattered hobnail endothelial cells Extramedullary hematopoiesis, fibrin thrombi, extensive perirenal fat entrapment, intravascular growth and mast cells may be seen (Histopathology 2014;65:309) Cytologic atypia and mitotic activity rare
- Pathology Outlines - Composite hemangioendothelioma
Distinctive intravascular growth of well differentiated columnar matchstick-like hobnail endothelial cells with eosinophilic cytoplasm and indistinct nucleoli (Am J Surg Pathol 1999;23:1004) Intraluminal papillary tufts with hyaline cores Varying degrees of stromal or intraluminal lymphocytes
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