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- What Is Integrase and What Is Its Function? - Biology Insights
Integrase is an enzyme whose fundamental role involves the precise cutting and pasting of genetic material, DNA, from one location to another This ability to manipulate genetic code is central to various biological processes
- PDB-101: Molecule of the Month: Integrase
Integrase is the enzyme that splices the viral DNA into a cellular chromosome Four identical copies of integrase grab the two ends of the viral DNA, creating a stable complex called an intasome
- The Integrase: An Overview of a Key Player Enzyme in the . . . - MDPI
Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into host genomes is a fundamental step in the replication cycle of all retroviruses
- Integrase | NIH - Clinicalinfo
HIV uses integrase to insert (integrate) its viral DNA into the DNA of the host CD4 cell Integration is a crucial step in the HIV life cycle and is blocked by a class of antiretroviral (ARV) HIV drugs called integrase strand transfer inhibitors (INSTIs)
- Structure and function of retroviral integrase | Nature Reviews . . .
Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with HIV
- Integrase - an overview | ScienceDirect Topics
Integrase is defined as an essential enzyme encoded by the HIV Pol gene that facilitates the integration of viral DNA genomes into human chromosomes through a series of DNA cutting and joining reactions
- Integrase: Structure, Function, and Mechanism | SpringerLink
Retroviral DNA integration is a multistep process that occurs in defined stages The viral-encoded integrase (IN) is both necessary and sufficient to catalyze integration (Katz et al 1990; Li and Craigie 2005; Sinha and Grandgenett 2005)
- Retroviral Integrase Structure and DNA Recombination Mechanism
Integrase cleaves specific phosphodiester bonds near the viral DNA ends during the 3′ processing reaction The enzyme then uses the resulting viral DNA 3′-OH groups during strand transfer to cut chromosomal target DNA, which simultaneously joins both viral DNA ends to target DNA 5′-phosphates
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