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- JCI - Welcome
In this issue of the JCI, Singh et al present a mouse model of a specific BBS subtype with genetic deletion of the Bbs5 gene The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that
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The Journal of Clinical Investigation; Current issue; Past issues; Specialties; Reviews; Review series; Videos; Conversations with Giants in Medicine
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The JCI was founded in 1924 and is published by the American Society for Clinical Investigation (ASCI), a nonprofit honor organization of physician-scientists established in 1908 Impact Factor 13 3 (2023) One of the top journals in the category “Medicine, Research Experimental ”
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Human T-lymphotropic virus type 1–associated (HTLV-1–associated) myelopathy (HAM, also known as tropical spastic paraparesis) is a rare neurodegenerative disease with largely elusive molecular mechanisms, impeding targeted therapeutic advancements
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The goal of this study was to determine if transplantation of enteric neural stem cells (ENSCs) can rescue the enteric nervous system, restore gut motility, reduce colonic inflammation, and improve survival in the Ednrb-KO mouse model of Hirschsprung disease (HSCR)
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