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- JMJD6 Gene - GeneCards | JMJD6 Protein | JMJD6 Antibody
JMJD6 (Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase) is a Protein Coding gene Diseases associated with JMJD6 include Pontocerebellar Hypoplasia, Type 2F and Pancreatitis Among its related pathways are Metabolism of proteins and Chromatin organization
- Targeting JMJD6: A Novel Approach in Cancer Therapy?
JMJD6 plays an important role in transcriptional regulation, RNA splicing, inflammation, and immune responses It downregulates pathways and activities like p53, TGF-β signaling, and Myc-induced apoptosis, while upregulating processes such as CDKs, WNT, MAPK, and autophagy pathways
- JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer . . .
Elevated JMJD6 and ATF4 coordinated enhancer–promoter loop interactions to stimulate the glutathione biosynthesis pathway Independent of androgen receptor, JMJD6 recruited mediator subunits (Med1 14) to assemble de novo enhancers mapping to pivotal genes associated with glutathione metabolism, including SLC7A11 , GCLM , ME1 , and others
- JMJD6 protein expression summary - The Human Protein Atlas
JMJD6 is a prognostic marker in Kidney renal papillary cell carcinoma, Liver hepatocellular carcinoma, Lung adenocarcinoma
- JMJD6 Autoantibodies as a Potential Biomarker for Inflammation . . . - MDPI
In this study, Jumonji C-domain-containing 6 (JMJD6) was identified by the serological identification of antigens through recombinant cDNA expression cloning In particular, JMJD6 is an antigen recognized in serum IgG from patients with unstable angina pectoris (a cardiovascular disease)
- 宣成昊教授课题组Cell Death Differ揭示JMJD6以不依赖于其酶活性的方式调控DNA损伤应答的分子机制
JMJD6基因敲低会提高HR（homologous recombination）以及NHEJ（nonhomologous end joining）的效率，促进细胞周期检验点恢复，增加IR之后细胞存活。 在分子机制方面，该研究发现含有JMJC结构域的JMJD6，尽管被报道具有组蛋白精氨酸去甲基化酶和羟化酶的活性，但在参与DNA损伤应答调控时并不依赖于其酶活性，JMJD6通过招募SIRT1到染色质上降低DSBs附近的H4K16ac水平实现对DNA损伤应答的调控。 该研究揭示了JMJD6是一个新的参与DNA损伤位点附近epigenome调控的表观遗传学因子，为更好的理解表观遗传学因子在DNA损伤应答中的作用提供基础。 该研究得到国家自然科学基金面上项目、科技部重点研发计划等资助。
- Cancer Res | 张传杰 高轶 徐丹枫等论述前列腺癌JMJD6驱动AR非依赖全新铁死亡防御机制
高表达JMJD6通过与ATF4形成表观复合物，且独立于BRD4 AR，劫持并重塑谷胱甘肽合成关键酶基因增强子，促进肿瘤细胞胱氨酸吸收及谷胱甘肽代谢成瘾，导致该类前列腺癌亚群天然铁死亡耐受。
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