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- From Undruggable to Unstoppable: A New Cancer Cure Target Emerges
The KRAS gene mutation, responsible for a quarter of all cancerous tumors, has met its match Thanks to UCSF research, a tiny “pocket” on a protein that signals the cells to grow and divide was discovered, leading to the world's first FDA-approved drugs that can now target and destroy these cancer cells
- KRAS - Wikipedia
KRAS acts as a molecular on off switch, using protein dynamics Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase
- What’s new in KRAS mutation research? - MD Anderson Cancer Center
The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers
- KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic . . .
Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid tumors Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for the structure of KRAS has been considered as being implausible to target for decades
- Unpacking the diversity among KRAS mutants | Frederick National Laboratory
The vast majority of patients harbor KRAS mutations and p53 alterations, a combination that yields poor outcomes and limited opportunities for tailored therapy 2-5 Though the most recent guidelines from the National Comprehensive Cancer Network advise molecular profiling for patients with advanced or metastatic pancreatic cancer, tumor features
- RNA therapy silences KRAS gene and boosts immune attack on cancer cells
KRAS is a gene that acts like a molecular switch controlling how cells grow and divide In healthy cells, this switch turns on and off as needed
- KRAS mutation: from undruggable to druggable in cancer
As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention The understanding of KRAS is constantly being updated by
- KRAS gene: MedlinePlus Genetics
The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS MAPK pathway The protein relays signals from outside the cell to the cell's nucleus
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