安裝中文字典英文字典辭典工具!
安裝中文字典英文字典辭典工具!
|
- KRAS - Wikipedia
KRAS acts as a molecular on off switch, using protein dynamics Once it is allosterically activated, it recruits and activates proteins necessary for the propagation of growth factors, as well as other cell signaling receptors like c-Raf and PI 3-kinase
- What’s new in KRAS mutation research? - MD Anderson Cancer Center
The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers
- KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic . . .
Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid tumors Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for the structure of KRAS has been considered as being implausible to target for decades
- KRAS “Cracked Open”: Karmanos Researchers . . . - McLaren Health Care
A major new review published in the high-impact Nature journal Signal Transduction and Targeted Therapy (impact factor >50) is reshaping the conversation around KRAS, one of the most historically “undruggable” oncogenes in human cancer The article, “ Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges ,” led by researchers at the Barbara Ann Karmanos
- The evolving landscape of RAS-targeted therapies - Nature
The initial discovery of an inhibitor of KRAS G12C revolutionized the KRAS field Since then, more-potent G12C-specific inhibitors, newer allele-specific inhibitors and combinations based on KRAS
- KRAS Mutations: Their Role in Cancer and Targeted Therapy
The KRAS gene belongs to a class of genes known as oncogenes, which can transform normal cells into cancerous ones when mutated These mutations can also cause chromatin rearrangements within cells, reverting tissue cells to an early developmental or “stem-like” state, initiating tumor formation
- Exploring KRAS: A precision approach in oncology - MSD
KRAS is one of the most frequently mutated oncogenes found in cancer In healthy cells, KRAS serves as an on-off switch that regulates cell growth However, when the gene is mutated, KRAS can become stuck in the “on” position, causing uncontrolled cancer cell growth and proliferation
- Hyperactive KRAS mutation triggers cell death in the pancreas
The new study, published in Cancer Research Communications, showed that a rare version of the KRAS gene hyperactivates a key cancer-driving pathway so intensely that pancreatic cells self-destruct – essentially burning out before becoming cancerous The findings shed light on new ways KRAS might be targeted in cancer
|
|
|