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- Comorbidities confound metabolomics studies of human disease
In this study, we investigated the impact of co-existing conditions on risk estimations for 1375 plasma metabolites in 919 individuals from population-based Estonian Biobank cohort using
- A comprehensive study of metabolite genetics reveals strong pleiotropy . . .
Here we aim to provide an integrated perspective of the genetic basis of metabolites by leveraging the Finnish Metabolic Syndrome In Men (METSIM) cohort, a unique genetic resource which
- Metabolite and protein associations with general health in the . . .
We examined cross-sectional metabolome and proteome data from 3,142 adults of the Cooperative Health Research in South Tyrol (CHRIS) study, an Alpine population study designed to investigate
- Association of circulating metabolites with healthy diet and risk of . . .
In the EPIC-Potsdam cohort study of 2380 adults, for example, dietary patterns were derived through reduced rank regression methods to explain the maximum variations of metabolites 5 and a weak
- Metabolomic profiles predict individual multidisease outcomes
We externally validated disease-specific metabolomic states in four independent cohorts analyzed with the same 1H-NMR metabolomics assay, the Whitehall II cohort 24, and three independent cohorts
- Association of circulating metabolites with healthy diet and risk of . . .
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk We aimed to identify metabolite profiles associated with high adherence to dietary recommendations - the Alternative Healthy Eating Index (AHEI) - and the extent to which metabolites associated with AHEI also predict incident CVD
- Plasma metabolites of a healthy lifestyle in relation to mortality and . . .
In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass-spectrometry to profile plasma metabolites, and ascertained deaths with death certificates The unique healthy lifestyle metabolomic signature was identified using an elastic regression
- Association between physical activity-related metabolic signature and . . .
We identified physical activity-related metabolites and constructed metabolic signature using linear regression and elastic net regression Association between physical activity, metabolic signature, and CMDs (type 2 diabetes [T2D], coronary heart disease [CHD], and stroke) were explored using Cox and mediation analyses
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