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- Lactam - Wikipedia
A lactam is a cyclic amide, formally derived from an amino carboxylic acid through cyclization reactions [1] The term is a portmanteau of the words lactone + amide
- β-Lactams and β-Lactamase Inhibitors: An Overview - PMC
β-Lactam antibiotics are currently the most used class of antibacterial agents in the infectious disease armamentarium As shown in Figure 1, β-lactams account for 65% of all prescriptions for injectable antibiotics in the United States
- Overview of Beta-Lactams - Infectious Diseases - Merck Manual . . .
Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes
- Lactam - an overview | ScienceDirect Topics
Lactam is defined as a cyclic amide that can be produced from raw materials and microorganisms through biotechnological processes, often related to the production of lactones
- 21. 11: Chemistry Matters—β-Lactam Antibiotics
Lactam antibiotics are essential in modern medicine Lactams, particularly β-lactams like penicillin and cephalosporins, inhibit bacterial cell wall synthesis by targeting peptidoglycan
- What is Lactam? - BYJUS
A four-atom ring known as alpha-lactam is present in all of these antibiotics’ molecular structures Antibiotics with alpha-lactams are used to prevent and cure bacterial infections caused by susceptible organisms
- β-Lactam antibiotic - Wikipedia
By definition, all β-lactam antibiotics have a β-lactam ring in their structure The effectiveness of these antibiotics relies on their ability to reach the PBP intact and their ability to bind to the PBP
- Advances in the chemistry of β-lactam and its medicinal applications
For the last couple of decades, a large number of β-lactam-based synthetic methods, collectively termed as “β-lactam-synthon method”, has been developed
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