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- Lactam - Wikipedia
A lactam is a cyclic amide, formally derived from an amino alkanoic acid through cyclization reactions The term is a portmanteau of the words lactone + amide Nomenclature
- β-Lactams and β-Lactamase Inhibitors: An Overview - PMC
β-Lactam antibiotics are bactericidal agents that interrupt bacterial cell-wall formation as a result of covalent binding to essential penicillin-binding proteins (PBPs), enzymes that are involved in the terminal steps of peptidoglycan cross-linking in both Gram-negative and Gram-positive bacteria
- Overview of Beta-Lactams - Infectious Diseases - Merck Manual . . .
Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes
- Beta-Lactam Antibiotics - StatPearls - NCBI Bookshelf
Beta-lactam antibiotics are used in the management and treatment of bacterial infections This activity will highlight the mechanism of action, adverse event profile, and other key factors (e g , off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of an interprofessional
- Lactam - an overview | ScienceDirect Topics
A lactam is a cyclic amide, which can be found in different forms: α-lactam (three-atom rings), β-lactam (four-atom rings), γ-lactam (five-atom rings), δ-lactam (six-atom rings), and ɛ-lactam (seven-atom rings) From: Green Approaches in Medicinal Chemistry for Sustainable Drug Design, 2020
- What is Lactam? - BYJUS
What is Lactam? A lactam is a cyclic amide, which is derived from an amino alkanoic acid The term is a portmanteau of the words acetone + amide Lactams form by the acid-catalysed rearrangement of oximes in the Beckmann rearrangement Lactams form from cyclic ketones and hydrazoic acid in the Schmidt reaction
- Lactam: What Is It? A Lactam is a Variety of Cyclic Amide
The amino group at one end reacts with the carboxylic acid group at the other, closing the molecule to form the ring This kind of ring is called a lactam The type of lactam is designated by using a Greek letter prefix that indicating the number of carbons in the ring, not counting the carbonyl group
- 21. 11: Chemistry Matters—β-Lactam Antibiotics
Lactam antibiotics are essential in modern medicine Lactams, particularly beta;-lactams like penicillin and cephalosporins, inhibit bacterial cell wall synthesis by targeting peptidoglycan The …
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