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- Genomics of Blood Pressure and Hypertension: Extending the . . .
The genetic architecture of blood pressure (BP) now includes more than 30 genes, with rare mutations resulting in inherited forms of hypertension or hypotension, and 1477 common single-nucleotide polymorphisms (SNPs) These signify the heterogeneity of the BP phenotype and support the mosaic theory …
- Genetics of Hypertension: From Monogenic Analysis to GETomics
Large-scale association studies that examine many gene polymorphisms simultaneously are crucial for predicting genetic risks Table 2 The principal discovered genes and their location, polymorphism, and genotype that play a role in arterial hypertension (HTN)
- Genomics of hypertension: the road to precision medicine
The genetic architecture of blood pressure encompasses approximately 30 genes, with rare variants involved in blood pressure dysregulation and >1,477 common single-nucleotide polymorphisms
- Genetic and Molecular Aspects of Hypertension | Circulation . . .
From an epidemiological perspective, a majority of individuals with hypertension have essential or primary hypertension, which is thought to result from a genetic predisposition underlying the cumulative effects of various lifestyle factors over many years with no single underlying cause identified for the high BP
- Polymorphisms Flashcards - Quizlet
For example, N N homozygotes can have quite low to quite high enzyme activities This could be due to each allele (e g , N) actually being a class of alleles It is also possible that this range in enzyme activities could be due to different genetic backgrounds
- Contribution of Genetic Polymorphisms in Human Health - PMC
In this article, we highlight the role of susceptibility biomarkers, i e , the genetic polymorphisms of individuals of different ethnicities, with particular attention to the risk factors in the response to specific exposures of Europeans
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