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- Exposure pathways, levels and toxicity of polybrominated diphenyl . . .
Human toxicity studies have shown that PBDEs have endocrine disruption, developmental and carcinogenic effects
- Polybrominated diphenyl ethers - Wikipedia
Lower-brominated PBDEs with 1–4 bromine atoms per molecule are regarded as more dangerous because they more efficiently bioaccumulate They have been known to affect thyroid hormone levels, and studies have linked them to reproductive and neurological risks at certain concentrations or higher [6]
- HEALTH EFFECTS
Limited human evidence is inconclusive regarding potential associations between diabetes and PBDE exposure; however, considering the animal data, the pancreas may be a target of concern for oral PBDE exposure
- ATSDR Polybrominated Diphenyl Ethers (PBDEs) Tox Profile
Information is available on the potential health effects of formerly used commercial PBDE mixtures (pentaBDE, octaBDE, and decaBDE) as well as several individual PBDE congeners
- Polybrominated Diphenyl Ethers (PBDEs) | US EPA
EPA is concerned that certain PBDE congeners are persistent, bioaccumulative, and toxic to both humans and the environment The critical endpoint of concern for human health is neurobehavioral effects
- Neurotransmitter Systems Affected by PBDE Exposure: Insights . . . - MDPI
Chronic exposure to PBDEs is associated with adverse human health effects, including cancer, immunotoxicity, hepatotoxicity, reproductive and metabolic disorders, motor and hormonal impairments, and neurotoxicity, especially in children
- Structural studies on the endocrine-disrupting role of polybrominated . . .
Specifically, the study involved structural binding characterization of BDE-47 and BDE-99 including their two HO- and two MeO- metabolites with thyroxine-binding globulin (TBG), which is the main thyroid hormone transport protein in blood
- Exposure and Toxicity of Polybrominated Diphenyl Ethers: A Mini Review
PBDEs with fewer bromine atoms are more volatile and prone to bioaccumulation, raising significant health concerns These compounds, often added physically to products, can leach into the
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