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- Clinical efficacy and mechanisms of biologics for chronic . . .
outcomes of biologic therapy versus endoscopic sinus surgery, and discuss therapies in development and future directions (J Allergy Clin Immunol 2025;155:1401-10 ) Key words: Chronic rhinosinusitis, nasal polyp, CRSwNP, CRSsNP, biologic, benralizumab, dupilumab, mepolizumab, omalizumab, tezepelumab Chronic rhinosinusitis (CRS) encompasses a
- Tezepelumab for Severe Chronic Rhinosinusitis with Nasal Polyps
2025-03-27 DOI: 10 1056 NEJMdo007940 In patients with chronic severe rhinosinusitis and nasal polyps, tezepelumab therapy led to greater reductions in polyp size and nasal congestion and less
- Efficacy and Safety of Biologics for Chronic Rhinosinusitis . . .
Dupilumab, omalizumab, mepolizumab, and benralizumab have demonstrated good efficacy and safety in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) in phase 3 randomised controlled trials (RCTs) With recent regulatory approvals, there has been a surge in real-w …
- Ultra-long-acting biological therapy for chronic . . . - The Lancet
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common and particularly severe subset of sinonasal inflammatory disease that is characterised by benign outgrowths of the inflamed mucosa The management framework of CRSwNP substantially shifted with the introduction of biological agents 1–3 These therapies, targeting the Th2 cell cytokine pathways, drove reductions in both systemic
- Dupixent Outperforms Xolair in First-Ever Head-to-Head Trial . . .
Key achievements include a 1 60-point greater reduction in nasal polyp size and an 8 0-point superior improvement in smell identification compared to Xolair Dupixent also showed significant advantages in nasal congestion reduction, symptom severity, and quality of life measures
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