Neurogenic inflammation - Wikipedia Neurogenic inflammation is inflammation arising from the local release by afferent neurons of inflammatory mediators such as substance P, calcitonin gene-related peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3) [1][2][3] For example, release of neuropeptides can increase vasodilatation and capillary permeability of vascular