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- NFE2L2 - Wikipedia
Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene [5]
- NFE2L2 Gene - GeneCards | NF2L2 Protein | NF2L2 Antibody
NFE2L2 (NFE2 Like BZIP Transcription Factor 2) is a Protein Coding gene Diseases associated with NFE2L2 include Immunodeficiency, Developmental Delay, And Hypohomocysteinemia and Squamous Cell Carcinoma, Head And Neck Among its related pathways are Nuclear events mediated by NFE2L2 and Infectious disease
- NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated with . . .
Our findings revealed the possible role of NFE2L2 across cancers, suggesting that NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in many cancers, especially in LGG
- NFE2L2 NFE2 like bZIP transcription factor 2 [ Homo sapiens (human) ]
Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells Jang J, et al Stem Cells, 2014 Oct PMID 24895273, Free PMC Article Polymorphism of Nrf2, an antioxidative gene, is associated with blood pressure and cardiovascular mortality in hemodialysis patients
- Nuclear factor, erythroid 2-like 2-associated molecular . . . - Nature
Nuclear factor, erythroid 2-like 2 (NFE2L2), a transcription factor also known as NF-E2-related factor 2 (Nrf2), is a key cytoprotective gene that regulates critical antioxidant and stress
- NFE2L2 - an overview | ScienceDirect Topics
NFE2L2 encodes a master transcription factor that is crucial for cellular redox homeostasis and oxidative stress response Hotspot missense mutations in the DLG and ETGF motifs have been reported in lung cancers [30] Recurrent NFE2L2 hotspot mutations were identified in HCC (8 125, 6 4%) [13]
- Nrf2 (NFE2L2) - Abcam
Nrf2 is a crucial transcription factor that plays a key role in the response to oxidative stress It binds to antioxidant response (ARE) element present in the promoter regions of many cell-protective genes In normal conditions, Nrf2 is ubiquitinated and degraded in the cytoplasm by the BCR (KEAP1) complex
- Targeting NFE2L2 KEAP1 Mutations in Advanced NSCLC With the TORC1 2 . . .
Shibata et al 9 characterized the oncogenic potential of activating mutations in NFE2L2, showing that HEK293 cells expressing NFE2L2 Neh2-domain mutations (T80R, L30F) exhibit increased proliferation, colony formation, and tumor growth in orthotopic mouse models
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