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- NF-κB - Wikipedia
NF-κB "NFKB" redirects here For the airport in Fiji, see List of airports by ICAO code: N § Fiji Mechanism of NF-κB action The classic "canonical" NF-κB complex is a heterodimer of p50 and RelA, [1] as shown NF-κB waits for activation in the cytosol, complexed with the inhibitory protein IκBα
- NF-κB in biology and targeted therapy: new insights and . . . - Nature
NF-κB signaling has been discovered for nearly 40 years Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses However, with extensive and in-depth
- The non-canonical NF-κB pathway in immunity and inflammation
Autoregulation of the NF-kB transactivator Rel A (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs Proc Natl Acad Sci USA 1994;91:1346–1350 doi: 10 1073 pnas 91 4 1346
- NF-κB in inflammation and cancer
Emerging evidence highlights the role of NF-kB in the epigenetic regulation of metastasis through mechanisms such as DNA methylation
- The NF-κB Family of Transcription Factors and Its Regulation
Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation, differentiation, and survival Inducible NF-κB activation depends on phosphorylation-induced proteosomal
- NFKB2 - Wikipedia
NF-κB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states NF-κB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products Inappropriate activation of NF
- NF-κB: blending metabolism, immunity, and inflammation
Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers Proc Natl Acad Sci U S A 2019; 116:9453-9462 Crossref Scopus (136)
- NF-κB signaling in inflammation | Signal Transduction and . . . - Nature
NF-κB target genes involved in inflammation development and progression NF-κB is an inducible transcription factor After its activation, it can activate transcription of various genes and
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