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- Name Reactions - Organic Chemistry Portal
Name Reactions Please use the following URL if you want to set a link: https: www organic-chemistry org namedreactions
- Gabriel Synthesis - Organic Chemistry Portal
Gabriel Synthesis Potassium phthalimide is a - NH 2 -synthon which allows the preparation of primary amines by reaction with alkyl halides After alkylation, the phthalimid is not nucleophile and does not react anymore Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product
- Suzuki Coupling - Organic Chemistry Portal
Suzuki Coupling The scheme above shows the first published Suzuki Coupling, which is the palladium-catalysed cross coupling between organoboronic acid and halides Recent catalyst and methods developments have broadened the possible applications enormously, so that the scope of the reaction partners is not restricted to aryls, but includes alkyls, alkenyls and alkynyls Potassium
- Chan-Lam Coupling - Organic Chemistry Portal
Chan-Lam Coupling This reaction allows aryl carbon-heteroatom bond formation via an oxidative coupling of boronic acids, stannanes or siloxanes with N-H or O-H containing compounds in air Substrates include phenols, amines, anilines, amides, imides, ureas, carbamates, and sulfonamides The reaction is induced by a stoichiometric amount of copper (II) or a catalytic amount of copper catalyst
- Sonogashira Coupling - Organic Chemistry Portal
Sonogashira Coupling This coupling of terminal alkynes with aryl or vinyl halides is performed with a palladium catalyst, a copper (I) cocatalyst, and an amine base Typically, the reaction requires anhydrous and anaerobic conditions, but newer procedures have been developed where these restrictions are not important
- Prevost Reaction - Organic Chemistry Portal
Mechanism of the Prevost Reaction The initial addition of iodine leads to a cyclic iodonium ion, which is opened through nucleophilic substitution by benzoate anion: A neighbouring-group participation mechanism prevents the immediate nucleophilic substitution of iodine by a second equivalent of benzoate that would lead to a syn -substituted product Instead, a cyclic benzoxonium ion
- Brown Hydroboration - Organic Chemistry Portal
Brown Hydroboration The syn -addition of hydroboranes to alkenes occurs with predictable selectivity, wherein the boron adds preferentially to the least hindered carbon This selectivity is enhanced if sterically demanding boranes are used Coupling the hydroboration with a subsequent oxidation of the new formed borane yields anti -Markovnikov alcohols The hydroboration oxidation sequence
- Overman Rearrangement - Organic Chemistry Portal
Overman Rearrangement The Overman Rearrangement allows the conversion of readily available allylic alcohols into allylic amines by a two-step synthesis involving the rearrangement of an allylic trichloroacetimidate to an allylic trichloroacetamide with clean 1,3-transposition of the alkenyl moiety Allylic amines are useful precursor of a variety of nitrogen-containing molecules, such as
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