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- PLX5622 | CSF1R Inhibitor | MedChemExpress
PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0 016 μM; Ki=5 9 nM) PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development
- Low-dose PLX5622 treatment prevents neuroinflammatory and . . .
Here, we investigated whether pharmacological depletion of microglia using PLX5622 (1200 ppm or 300 ppm) in the acute phase of sepsis is able to prevent long-term neurocognitive decline in a male mouse model of polymicrobial sepsis or lipopolysaccharide-induced sterile neuroinflammation
- Sustained microglial depletion with CSF1R inhibitor impairs . . . - Nature
Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622)
- PLX5622 | CSF1R Inhibitor | CAS 1303420-67-8 | Selleck Chemicals
PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol L), showing > 20-fold selectivity over KIT and FLT3 In vivo PLX5622 demonstrates desirable PK properties in mice, rats, dogs, and monkeys, with a brain penetrance of ~20%
- More than microglial depletion: PLX5622 activates the hepatic . . .
In this study, we demonstrate that PLX5622 treatment specifically accelerates injectable anesthesia rather than inhalation anesthesia
- PLX5622: A Technical Guide to a Selective CSF1R Inhibitor for Microglia . . .
This guide provides a comprehensive overview of PLX5622, including its mechanism of action, pharmacokinetic properties, and detailed experimental protocols for its use in microglia depletion studies
- PLX5622 | CSF1R inhibitor | elimination of microglia | TargetMol
PLX5622 is an orally active small-molecule CSF1R inhibitor that selectively depletes microglia in the brains of mice and rats It is commonly used to establish models related to microglia-associated neuroinflammation, neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease), brain injury, and neuroimmune regulation
- PLX5622 (CAS Number: 1303420-67-8) | Cayman Chemical
Dietary administration of PLX5622 (1,200 ppm in chow) decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical amyloid-β (Aβ) plaques in the 5XFAD transgenic mouse model of Alzheimer's disease 1
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