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- PRAME - Wikipedia
PRAME (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene [3][4][5] Five alternatively spliced transcript variants encoding the same protein have been observed for this gene
- Pathology Outlines - PRAME
PRAME (preferentially expressed antigen in melanoma) is a cancer testis antigen expressed by melanoma and other malignant neoplasms with expression in normal tissue largely restricted to testis
- What Does a Positive PRAME Test Mean for Melanoma?
PRAME testing is ordered when a pathologist examines a biopsied skin lesion difficult to classify based on traditional microscopic features alone The test provides molecular confirmation that helps distinguish between a benign lesion, like a nevus, and a malignant melanoma
- PRAME: Definition – MyPathologyReport
PRAME stands for “preferentially expressed antigen in melanoma ” It is a special type of protein called a cancer-testis antigen This means that PRAME is usually found in cancer cells and normal cells within the testis, but rarely in other normal tissues of the body
- PRAME in Melanoma: Diagnosis, Prognosis, and Treatment
PRAME, or “Preferentially expressed Antigen in Melanoma,” is a protein found on cancer cells that can be recognized by the immune system
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- Autologous T cell therapy for PRAME - Nature
This work clinically validates PRAME as a target for treatment of multiple solid cancers and points to a new benchmark for a high rate of durable response in patients with last-line melanoma
- PRAME: What Is It and Should My Lab Be Using It?
PRAME has low to no expression in regular tissue (except for a few such as testis and ovaries) but high expression in malignant cells, particularly in primary and metastatic melanomas, making it a valuable marker for melanoma diagnosis, though it has also been used in other types of cancer diagnosis including leukemia, lymphoma, breast cancer
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