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- Propofol-Related Infusion Syndrome: A Clinical Review - PMC
Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients
- Propofol-related Infusion Syndrome • LITFL • CCC Pharmacology
Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:
- Propofol infusion syndrome - Wikipedia
Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol
- Propofol Related Infusion Syndrome - DFW Anesthesia Professionals
Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly
- Propofol Infusion Syndrome? – ResusNation
Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990 It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest
- Propofol-Related Infusion Syndrome (PRIS)
Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism
- Propofol Related Infusion Syndrome (PRIS) - First10EM
Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease
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