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- Ionizable lipid nanoparticles deliver mRNA to pancreatic β . . . - Science
Proc Natl Acad Sci U S A 18, e2109256118 (2021) S T LoPresti, M L Arral, N Chaudhary, K A Whitehead, The replacement of helper lipids with charged alternatives in lipid nanoparticles facilitates targeted mRNA delivery to the spleen and lungs J Control Release 345, 819–831 (2022)
- Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via . . .
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer Sci Adv 2023 Jan 27;9 (4):eade1444 doi: 10 1126 sciadv ade1444 Epub 2023 Jan 27
- Sci Adv：巨噬细胞外泌体协助将LNP-mRNA疗法的mRNA递送至胰腺β细胞 - 外泌体资讯网
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer Sci Adv 2023 Jan 27;9 (4):eade1444 doi: 10 1126 sciadv ade1444 Epub 2023 Jan 27 PMID: 36706177 外泌体资讯网 Sci Adv：巨噬细胞外泌体协助将LNP-mRNA疗法的mRNA递送至胰腺β细胞
- lt;br gt;可电离的脂质纳米粒子通过巨噬细胞介导的基因转移将 mRNA 递送至胰腺 β 细胞,Science Advances - X-MOL
可电离的脂质纳米粒子通过巨噬细胞介导的基因转移将 mRNA 递送至胰腺 β 细胞 Science Advances ( IF 11 7 ) Pub Date : 2023-01-27 , DOI: 10 1126 sciadv ade1444
- RNA靶向递送系列 | 胰腺靶向LNP研究进展_胰岛_腹膜_辅助
2023年，卡内基梅隆大学Kathryn A Whitehead教授作为通信作者在Science子刊Science Advances发表胰腺靶向LNP-mRNA的研究成果。 他们测试了3种可电离类脂质（306Oi10, 200Oi10, 或514O6,10）和3种辅助脂质（两性离子辅助脂质DOPE、阴离子辅助脂质PS或阳离子辅助脂质DOTAP）。
- Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via . . .
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer Science Advances ( IF 11 7 ) Pub Date : 2023-01-27 , DOI: 10 1126 sciadv ade1444
- Science Advances | AAAS
Science Advances—AAAS’s gold open-access journal—publishing innovative, peer-reviewed research and reviews across a range of scientific disciplines
- Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via . . .
Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs remains challenging To overcome this issue, we hypothesized that altering nanoparticle chemistry and administration routes may enable mRNA-induced protein expression outside of the reticuloendothelial system Here, we describe a strat-egy for delivering mRNA potently and specifically to the pancreas using
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