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- Pharmacological inhibition of PSPH reduces serine levels and . . . - Nature
d-Serine is needed for glutamate-induced epileptic seizures Sha and Wang et al found that l-serine produced by astrocytes positively correlates with d-serine level in neurons and identified a
- Serine Protease, Enzyme Catalysis | Learn Science at Scitable
The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase
- Serine and one-carbon metabolism in cancer - Nature
Serine supports many biosynthetic pathways, including the one-carbon cycle This Review discusses how cancer cells acquire and use serine, and explores novel therapeutic approaches to limit serine
- Phospho-tau serine-262 and serine-356 as biomarkers of pre . . . - Nature
Two new phosphorylation sites, p-tau262 and p-tau356, detect the formation of prefibrillar tau aggregates and may serve as early-stage biofluid-based biomarkers of tau neurofibrillary tangle
- Serine synthesis through PHGDH coordinates nucleotide levels by . . .
Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis Paradoxically, PHGDH and serine synthesis are required in the presence of abundant environmental
- Cellular redox state constrains serine synthesis and . . . - Nature
Cancer cells increase serine synthesis; however, exogenous serine is required for maximal proliferation Here the authors show that the demand for oxidized NAD+ constrains serine synthesis, which
- An epidermal serine sensing system for skin healthcare
Serine is an important biomarker for skin healthcare Here, the authors introduce a portable epidermal sensing system capable of direct sampling and in situ quantification of serine on the skin
- The impact of physiological metabolite levels on serine uptake . . .
Serine is a non-essential amino acid that is critical for tumour proliferation and depletion of circulating serine results in reduced tumour growth and increased survival in various cancer models
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