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- Pathology Outlines - Anatomy histology
Mucosa is composed of the epithelium, lamina propria and muscularis mucosa Epithelium: colonic epithelium is composed of a single layer of the absorptive columnar cells and the goblet cells As the epithelium invaginates into the underlying lamina propria, it forms glandular structures called crypts, arranged in a characteristic parallel test
- What does colonic mucosa without histologic abnormality mean?
Colonic mucosa with hyperplastic changes refers to an overgrowth of cells in the mucous lining of the colon Xanthomas are collections of lipids in the tissues, which can appear as yellowish patches
- Pathology Outlines - Lymphoid polyp
Colonic mucosa with lymphoid aggregate; otherwise, with no significant histopathologic findings (see comment) Comment: The mucosal lymphoid tissue shows polymorphous population of lymphoid tissue There is an admixture of CD20 positive B cells and CD3 positive T cells CD45 stain shows no aberrant expression in the regions stained by CD20
- Pathology Outlines - Collagenous colitis
Rarely, mucosal tears or perforation can occur during endoscopy, likely as a result of decreased colonic wall compliance (Dig Liver Dis 2017;49:1073) Association with other autoimmune diseases (Lancet Gastroenterol Hepatol 2019;4:305, Am J Gastroenterol 2017;112:78, Frontline Gastroenterol 2019;10:388):
- Pathology Outlines - Inflammatory polyp
Often consists of normal colonic mucosa in a polypoid configuration, with increased inflammation (expanded lamina propria and crypt abscesses or cryptitis) Epithelium can show various degrees of surface erosion, crypt distortion dilation or hyperplasia, along with reactive nuclear features within the mucosal epithelial cells
- Pathology Outlines - Lymphoid aggregates (benign)
Benign lymphoid aggregates show predominantly patterns 1 - 3 with rare cases of patterns 4 and 5 Atypical features described in lymphoid aggregates include large size, infiltrative borders, paratrabecular location and predominance of B cells (patterns 4 and 5)
- Pathology Outlines - Lymphocytic colitis
Colonic intraepithelial lymphocytosis (> 20 per 100 enterocytes) with diffuse increase in lamina propria inflammatory cells ICD coding ICD-10: K52 832 - lymphocytic colitis
- Pathology Outlines - Ulcerative colitis
Pseudopolyp formation due to ulceration with intervening areas of preserved mucosa Filiform polyposis is an exaggerated form of pseudopolyp formation and shows elongated, finger-like mucosal projection Toxic megacolon shows marked dilation and thinning of the colonic wall References: Virchows Arch 2014;464:511, Virchows Arch 2018;472:81
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