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- Sickle Cell Disease - What Is Sickle Cell Disease? - NHLBI, NIH
Sickle cell disease affects more than 100,000 people in the United States and 8 million people worldwide In the United States, 9 of 10 people who have sickle cell disease are of African ancestry or identify as Black: About 1 in 13 Black babies are born with sickle cell trait,meaning that they inherited a sickle cell gene from one parent
- Sickle Cell Disease - Causes and Risk Factors - NHLBI, NIH
This child has sickle cell trait and is a carrier of the gene for hemoglobin S A 25%, or 1 in 4, chance of inheriting two copies of the gene for hemoglobin S This child has sickle cell disease A child with sickle cell disease may also have one copy of the gene for hemoglobin S and one copy of a gene for another faulty hemoglobin
- Sickle Cell Disease: Research, Programs, and Progress
Sickle cell disease (SCD) is a group of painful and life-threatening genetic disorders that affect hemoglobin, the major protein that carries oxygen in red blood cells It occurs in nearly 100,000 people in the
- Sickle Cell Disease - Treatment | NHLBI, NIH
Hydroxyurea is an oral medicine that is frequently prescribed to help treat sickle cell disease Hydroxyurea is an oral medicine that can reduce sickling of red blood cells and help prevent serious symptoms of sickle cell disease, including pain crises Healthcare providers usually prescribe daily hydroxyurea for infants as young as 9 months
- Sickle Cell Disease - Symptoms - NHLBI, NIH
Serious symptoms of sickle cell disease are emergencies and need treatment right away Seek care or call 9-1-1 if you or someone else is experiencing: Severe pain A serious pain event is sometimes called a “pain crisis,” “sickle cell crisis,” or “vaso-occlusive crisis ” Most people with sickle cell disease have this often-serious pain
- Evidence-Based Management of Sickle Cell Disease: Expert Panel Report . . .
The purpose of these guidelines is to help people living with sickle cell disease (SCD) receive appropriate care by providing the best science-based recommendations to guide practice decisions The target audience is primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with SCD
- Sickle Cell Disease Research - NHLBI, NIH
The Sickle Cell Genetics and Pathophysiology Lab studies the genetic and biological factors underlying the variability of sickle cell disease symptoms and complications NHLBI scientists are using the ReFRAME Drug Repurposing Library, which lists medicines that are approved by the FDA and have the potential to treat or prevent sickle cell pain
- NIH statement on new FDA-approved gene therapies for sickle cell . . .
Affordable sequencing technology is critical to the diagnosis of sickle cell disease NIH researchers successfully edited the disease-causing mutation in blood-forming cells taken directly from people with sickle-cell disease One of the new sickle cell treatments uses the CRISPR gene-editing system, a first for humans in the U S
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