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- Interleukin 3 - Wikipedia
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31 1 [ 3 ] [ 4 ] Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: after removal of the signal peptide sequence, the mature protein contains 133 amino acids in its
- IL-3: key orchestrator of inflammation - Frontiers
IL-3 plays an important role in bones by directly targeting both osteoblasts and osteoclasts IL-3 promotes the differentiation of human mesenchymal stem cells into osteoblasts and stimulates the formation and the survival of mononuclear osteoclasts
- What Is Interleukin-3 and What Does It Do? - Biology Insights
IL-3 is a hematopoietic growth factor, meaning it is involved in blood cell formation Its structure as a single polypeptide chain of 133 amino acids allows it to interact with specific receptors on target cells This interaction initiates a cascade of internal signals that guide a cell’s future The main purpose of IL-3 is to regulate the
- Interleukin 3 - an overview | ScienceDirect Topics
Interleukin-3 (IL-3) is a cytokine that binds to a receptor composed of IL-3Rα and βc subunits, stimulating the growth of various progenitor cells and promoting the survival of macrophages, mast cells, and megakaryocytes
- IL3 Gene - GeneCards | IL3 Protein | IL3 Antibody
antibodies-online: Show 74 available IL-3 Proteins ranked by validation data; Compare Top IL-3 Proteins
- Interleukin-3 in hematology and oncology: current state of . . . - PubMed
Interleukin (IL)-3 is a multipotent hematopoietic growth factor produced by activated T cells, monocytes macrophages and stroma cells The human IL-3 gene is located on chromosome 5 near segment 5q31 The high-affinity receptor for human IL-3 is composed of alpha and beta subunits
- Interleukin-3 coordinates glial-peripheral immune crosstalk to incite . . .
IL-3 signaling instigated a chemotactic program by IL-3Rɑ + myeloid cells that perpetuated immune cell recruitment to the CNS and worsened clinical severity In humans, we found that IL-3 is present in the CSF and correlated with disease diagnosis and severity
- Interleukin-3 amplifies acute inflammation and is a potential . . . - Science
Although antibiotics can help to quash the infection, sepsis patients also need therapies that will rein in the immune response Weber et al now identify one potential target, the secreted protein interleukin-3 (IL-3) (see the Perspective by Hotchkiss) In sepsis patients, higher serum concentrations of IL-3 were correlated with higher rates
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