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- TREM2 | ALZFORUM
TREM2 is a member of the immunoglobulin superfamily Endogenous ligands of this receptor are unknown but when triggered, it signals through the transmembrane adapter protein TYROBP DAP12 to activate phagocytosis of pathogens and cellular debris
- TREM2 - ALZFORUM
TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival TREM2 variants cause Nasu-Hakola disease (NHD), a rare autosomal recessive early-onset dementia, and may modify the risk of developing Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis
- All Roads Lead to TREM2: Gearing Up to Target This Receptor
Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease Findings presented at the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to
- Ferried Into Brain, TREM2 Antibody Stirs Microglia | ALZFORUM
TREM2 antibody sports transferrin receptor binding domain to ease entry into brain It activated microglia and boosted brain glucose metabolism The antibody is in a first Phase 1 trial
- TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques
A separate study that involved some of the same authors provides more clues to how TREM2 does this Researchers led by Huaxi Xu at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, reported that TREM2 directly binds Aβ This binding triggers microglia to activate, secrete cytokines, and degrade the internalized
- TREM2: A Chill Pill for Neurons? | ALZFORUM
TREM2 created quite the buzz at this year’s AD PD meeting, held April 1-5 in Vienna In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase trials of a fresh batch of agonists Juxtaposing this were presentations that unveiled a new modus operandi for
- TREM2 R47H - ALZFORUM
Soluble TREM2 (sTREM2) is produced by proteolytic processing of the protein R47H sTREM2 was slightly less effective than wild-type sTREM2 in stimulating microglial production of the pro-inflammatory cytokines IL-1β, IL-6, TNFα and promoting microglial survival after trophic factor (GM-CSF) withdrawal (Zhong et al , 2017)
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