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- New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease In the February 10 Nature Medicine, researchers led by Thomas Karikari, University of Pittsburgh, unveil their
- BIIB080 - ALZFORUM
Background This investigational therapeutic is the first antisense oligonucleotide (ASO) targeting tau expression to enter clinical trials Developed by IONIS in collaboration with Timothy Miller at Washington University, St Louis, ASOs that inhibit the translation of tau mRNAs into protein have been shown to reduce toxin-induced seizures, neuronal loss, and neurofibrillary pathology in adult
- Etalanetug - ALZFORUM
Background This humanized, monoclonal IgG1 antibody recognizes an HVPGG epitope in the microtubule-binding domain near the mid-domain of tau This region is a predominant component of tau tangles and is involved in seeding and spreading pathological tau aggregates The antibody is intended to bind extracellular tau, prevent cell-to-cell propagation of pathogenic species, and mediate clearance
- MAPT | ALZFORUM
MAPT encodes the microtubule associated protein tau, a protein central to Alzheimer’s disease neuropathology Most pathogenic genetic variants in MAPT are not linked to Alzheimer’s disease, however They are associated with diseases in the frontotemporal dementia (FTD) spectrum Located in exons or introns, they generally alter the relative production of tau isoforms, and or lead to
- Gosuranemab - ALZFORUM
Background This is a humanized IgG4 monoclonal anti-tau antibody In April 2014, Bristol-Myers Squibb acquired iPierian, a biotechnology company that had developed IPN007, an antibody against extracellular, N-terminal fragments of tau (eTau) that were originally isolated from familial AD patient-derived pluripotent stem cells The rationale for this therapeutic approach is that eTau is
- Tau PET Aligns Spread of Pathology with Alzheimer’s Staging
Tau accumulates in the brain in Alzheimer’s disease, but also during normal aging Can PET scans tell the difference? Two recent papers say yes, and propose schemes for imaging-based staging that until now was possible only at autopsy As reported in the March 2 Neuron, scientists led by Bill
- APOE R154S (Christchurch) - ALZFORUM
Consistent with these findings, tau spreading and neurotoxicity were attenuated in both AD (5xFAD) and tauopathy (P301S) mouse models carrying APOE3ch However, as noted above, other studies suggest Christchurch protects against tau pathology by enhancing, rather than decreasing, tau uptake by myeloid cells (Chen et al , 2023)
- HMTM - ALZFORUM
Tau pathology is widely considered to be downstream of Aβ pathology and is more closely linked to cognitive deficits in Alzheimer's disease Mutations in the tau gene cause frontotemporal dementia, not Alzheimer's disease, but tau is considered a central drug target for all tauopathies, including Alzheimer's
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