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- Etalanetug - ALZFORUM
Background This humanized, monoclonal IgG1 antibody recognizes an HVPGG epitope in the microtubule-binding domain near the mid-domain of tau This region is a predominant component of tau tangles and is involved in seeding and spreading pathological tau aggregates The antibody is intended to bind extracellular tau, prevent cell-to-cell propagation of pathogenic species, and mediate clearance
- NIO752 - ALZFORUM
NIO752 is an antisense oligonucleotide to tau, designed to reduce the levels of this protein by interfering with translation of tau mRNA The antisense strategy assumes that decreasing the abundance of tau will slow the formation of tau aggregates and progression of tau pathology
- BIIB080 - ALZFORUM
Background This investigational therapeutic is the first antisense oligonucleotide (ASO) targeting tau expression to enter clinical trials Developed by IONIS in collaboration with Timothy Miller at Washington University, St Louis, ASOs that inhibit the translation of tau mRNAs into protein have been shown to reduce toxin-induced seizures, neuronal loss, and neurofibrillary pathology in adult
- Tau P301S (Line PS19) - ALZFORUM
This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues As first reported in 2007 on a mixed background, PS19 mice develop neuronal loss and brain atrophy by eight months, principally in the hippocampus
- New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease In the February 10 Nature Medicine, researchers led by Thomas Karikari, University of Pittsburgh, unveil their
- Tau (Alz-50) - ALZFORUM
Alz-50 recognizes tau filaments Electron micrograph showing Alz-50-immunoreactive filaments in the hippocampus of an aged 3xTg-AD mouse Immunoperoxidase technique Right panel is a magnified view of the region outlined by the box in the left panel Scale bars: left, 0 5 μm; right, 200 nm From Oh et al , 2010; Figure 14i,j; licensed under Creative Commons BY 3 0
- Tau (CP-13) - ALZFORUM
This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202 Recognizes tau phosphorylated at serine 202 Immunoreactivity present in Alzheimer’s disease and other tauopathies Immunoreactivity absent in
- JNPL3 (P301L) - ALZFORUM
As originally described, the hemizygous animals express human tau at levels comparable to endogenous murine tau, whereas homozygotes express human tau at approximately twice endogenous levels Transgene expression was strongest in the cerebellum and hippocampus, followed by the thalamus, hypothalamus, spinal cord, brainstem and cortex
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