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- New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Tau pathology in humans or animals, without fail, is made up of the hyperphosphorylated protein In AD tau is hyperphosphorylated sub-stoichiometrically at multiple sites by several combinations of protein kinases Six isoforms of tau in the human brain and hyperphosphorylation at multiple sites in AD generate numerous protein species
- Night-Night, Neurodegeneration: Sleep Aid Lulls Tau Pathology
A different sleep drug, the GABA A modulator zolpidem, had no such effect, with mice bearing the full brunt of tau pathology (image below) Females, whose atrophy was milder, reaped little benefit from either therapy Goodnight, Degeneration: Vehicle-treated P301S E4 mouse show tau’s toll: swollen ventricles and a thinned hippocampus (left
- Heavy Tau Snuffs Out Hippocampal Bursts | ALZFORUM
Shushed by Tau Left: In patch-clamp setup, tau from AD brain is loaded into the recording pipette and diffuses into the CA1 neuron with which the pipette has made its seal Middle: Immunofluorescence image showing successful delivery of tau, with biocytin (green) marking the neuron, Tau-13 antibody staining infused tau (red)
- Tau (AT8); Phospho Tau (Ser 202, Thr 205) | ALZFORUM
Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease Recognizes paired helical filament (PHF) tau Phosphorylation at serine 202 and threonine 205 is required for recognition by AT8
- Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid plaques and of neurofibrillary tangles, with postmortem plaque and tangle load, and with cognitive test scores better than plasma total tau and neurofilament light, the currently available blood markers of neurodegeneration
- Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
By contrast, tau aggregates were neatly ordered, with uniform, evenly spaced fibrils arranged into bundles Many of these tau filaments resembled the paired helical filaments characteristic of AD But surprisingly, others looked more like fibrils found in people with chronic traumatic encephalopathy (CTE)
- Could “Big Tau” Protect Brain Regions from Tangles?
The new experimental findings strongly support predictions that the elongated projection domain of big tau, generated by exon 4a (with extra 250 amino acids), endows it with protective properties against the toxic misfolding, aggregation, and propagation of lower molecular weight tau that result in degeneration of the cognitive centers of the
- Tau Global Conference Promises Primary Tauopathy Trials
From April 24-25, the Tau Global Conference, a k a Tau2025, drew 600 people to a hotel in Hyde Park, London, with 500 more following the science online Attendance well surpassed Tau2020, the first, and only other, in-person gathering of this series Tau2025’s program committee was co-chaired by
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