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- New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease In the February 10 Nature Medicine, researchers led by Thomas Karikari, University of Pittsburgh, unveil their
- Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
“The fidelity of intracellular tau seeding allowed unbiased classification of tauopathies [by this assay] ” That this seeding-based technique aligns so well with the tauopathy family tree traced by cryo-EM structures adds credence to the prion-like properties of tau propagation, Diamond and colleagues believe
- ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time It showed that ApoE3Ch clings onto tau monomers immobilized on sensor chips approximately eight times more tightly than does wild-type ApoE3 Similarly, in neuroblastoma cells, glutathione S-transferase-labelled tau and GFP-tagged ApoE3Ch bound tightly (image at right)
- Night-Night, Neurodegeneration: Sleep Aid Lulls Tau Pathology
The tau phospho-epitope selectivity, PKA dependent phosphorylation, and GPCR phosphorylation-dependent signaling pathways analyzed pointed to mechanisms that define how reducing hyperarousal may work to improve pathology
- Heavy Tau Snuffs Out Hippocampal Bursts | ALZFORUM
Tau pulls the plug on the neural activity that forms memories, according to researchers led by Marc Aurel Busche at the U K Dementia Research Institute at University College London On April 23 in Cell, they showed that soluble tau silences complex spike bursts in hippocampal neurons in mice These
- Tau (AT8); Phospho Tau (Ser 202, Thr 205) - ALZFORUM
Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease Recognizes paired helical filament (PHF) tau Phosphorylation at serine 202 and threonine 205 is required for recognition by AT8
- Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid plaques and of neurofibrillary tangles, with postmortem plaque and tangle load, and with cognitive test scores better than plasma total tau and neurofilament light, the currently available blood markers of neurodegeneration
- Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
The new study takes this “in-tissue” analysis to the next level, zooming in on the intricate molecular architecture of Aβ plaques and tau inclusions in the brain of a person who died with advanced AD Co-first authors Madeleine Gilbert, Nayab Fatima, Joshua Jenkins, and Thomas O’Sullivan and colleagues obtained brain samples from the mid-temporal gyrus of this donor, who had developed
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