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- Lenalidomide - ALZFORUM
Lenalidomide is structurally similar to thalidomide, and as such is considered a teratogen with the potential to cause birth defects and fetal death Lenalidomide is being pursued as an alternative to thalidomide, whose development for AD was stopped because of dose-limiting toxicity in elderly patients (Decourt et al , 2017) Both drugs have
- New Arrows Aimed at Tau: Single-Domain Antibody, Peptibody, Vaccine
When the scientists conjugated this sdAb to thalidomide to bind E3 ubiquitin ligase and trigger degradation of the complex, the treatment nearly eliminated aggregated α-synuclein Sigurdsson believes sdAbs have potential as both therapeutics and PET ligands, and has a paper coming out on the latter later this month Trim the Tau
- Timeline - Inflammation - ALZFORUM
Inflammation 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
- Timeline - APP and Amyloid-Related - ALZFORUM
Amyloid-Related 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
- Getting to First BACE: BACE1 Inhibition Takes a Step Forward
Banner Health is now preparing a Phase 2 clinical trial led by Shen and Sabbagh to test the effectiveness of thalidomide at lowering Aβ, sAPPβ, and BACE1 levels in plasma and CSF, Sabbagh said They were able to skip a Phase 1 trial, he said, because thalidomide is already an FDA-approved drug, and its safety and side effects, which include
- Timeline - Small Molecule - ALZFORUM
Small Molecule 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
- International Conference on Alzheimers and Parkinsons . . . - ALZFORUM
Pumping Up Progranulin: Scientists Show New Efforts to Get It Done 07 Apr 2023 Queen Silvia of Sweden opened the 17th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to April 1 in Sweden's southwestern city of Gothenburg
- Therapeutics Search | ALZFORUM
Thalidomide: Thalomid® Alzheimer's Disease (Discontinued) Celgene Corporation: Amyloid-Related, Inflammation: Small Molecule: TPN-101: OBP-601, BMS-986001, censavudine, festinavir, 4'-ethynyl stavudine, 4'-ethynyl-d4T: ALS-FTD (Phase 2), Progressive Supranuclear Palsy (Phase 2) Transposon Therapeutics: Inflammation: Small Molecule, DNA RNA
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