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- Inflammation balance in skeletal muscle damage and repair
As pro-inflammatory mediators, specific DAMPs released from the skeletal muscle, including HMGB1 (15–17), ATP (18, 19), and mitochondrial DNA (20, 21), induce the secretion of pro-inflammatory cytokines and chemokines to trigger inflammation through TLR4 RAGE, P2X7R, and TLR9 on infiltrating tissue-resident macrophages and neutrophils
- P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis . . .
In skeletal muscle, fibroblasts produce the amority of the extracellular matrix (ECM) [11, 12] even though they only account for a small number of cells [13] These fibroblasts reside in the interstitial space between muscle fibers and play a critical role in maintaining muscle structure
- Mechanisms of cooperative cell-cell interactions in skeletal muscle . . .
Skeletal muscle stem cells, called satellite cells, play a central role in muscle regeneration via three major steps: activation, proliferation, and differentiation These steps are affected by multiple types of cells, such as immune cells, fibro-adipogenic progenitor cells, and vascular endothelial cells
- Interactions between muscle stem cells, mesenchymal-derived cells and . . .
Functional interactions between muscle stem cells (satellite cells), FAPs and cells from the inflammatory infiltrate have recently been reported and appear to determine the ability of
- cytokine expression and secretion by skeletal muscle cells: regulatory . . .
skeletal muscle cells themselves are the main source of cytokine gene expression in skeletal muscle during exercise In this review, we examine this notion in more detail by (1) reviewing the findings from studies of cytokine expression and secretion in cultured skeletal muscle cells, and (2) sum -
- Temporal dynamics of the interstitial fluid proteome in human skeletal . . .
The skeletal muscle interstitial space is the extracellular region around myofibers and mediates cross- talk between resident cell types We applied a proteomic workflow to characterize the human skeletal muscle interstitial fluid proteome at rest and in response to exercise Following exhaustive exercise, markers of skeletal muscle damage
- Muscle interstitial cells a field guide - University College London
populations resident in the skeletal muscle interstitium have been identified as “collaborators” of satellite cells during regeneration They also appear to have a key role in replacing skeletal muscle with adipose, fibrous or bone tissue in pathological conditions
- Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation
Triggers and mediators participating in protein and cell turnover of the skeletal muscle Insulin growth factor (IGF)-1, leads to insulin receptor substrate-1 (IRS-1) phosphorylation Subsequently, Akt becomes phosphorylated and activates the mammalian target of rapamycin (mTOR)-C1, thus contributing to protein synthesis and myoblast proliferation
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